Sentragortech公司的特色试剂SenTraGor™ （GL13）用于检测细胞衰老。细胞衰老是参与正常胚胎和成年生活的生物过程，并随着年龄的增长而增加。它也发生在各种疾病的框架内和治疗干预之后。衰老细胞的检测和测量在研究和临床实践中至关重要且非常需要。衰老细胞存在于广泛的年龄相关疾病中，包括癌症。SenTraGor™是一种与生物素偶联的SBB类似物，与已被证明在衰老过程中积累的脂褐素颗粒发生反应。

SenTraGor™ （GL13） 是一种用于检测衰老的创新试剂。衰老细胞在正常发育、组织稳态、衰老和广泛的年龄相关疾病中起着重要作用。到目前为止，衰老领域的一个主要问题是缺乏可靠的标记物来特异性检测这些细胞，尤其是原位细胞。SenTraGor™ （GL13） 是一种生物素化的苏丹黑 B 基化学试剂，旨在克服这一限制。

SenTraGor™ （GL13） 染色可以检测任何生物材料中的衰老。衰老细胞的直接可视化可以在所有档案组织标本（福尔马林固定石蜡包埋）和来自活检或细胞培养物的细胞中实现。

SenTraGor™被推荐用于识别衰老细胞。它与细胞质脂褐素结合，这是衰老细胞的标志。它可以应用于抽吸或细胞培养物的细胞以及来自冷冻或福尔马林固定石蜡包埋 （FFPE） 样品的组织切片。它可用于免疫组织化学（IHC），免疫细胞化学（ICC），免疫荧光（IF）和流式细胞术分析（FACS）。需要应用混合组织化学/免疫组织化学测定来产生一致和特异性的信号。使用针对一级抗生物素抗体的一抗和二抗。

Cellular senescence is a biological process involved in normal embryonic and adult life and increases with age. It also occurs in the frame of various diseases and after therapeutic interventions. Detection and measurement of senescent cells is critical and highly desired in research and clinical practice. Senescent cells are found in a wide spectrum of age related disorders, including cancer. SenTraGor™, an SBB analogue conjugated with biotin, reacts with lipofuscin granules that have been shown to accumulate during the senescence process.

SenTraGor™ (GL13) is an innovative reagent for the detection of senescence. Senescent cells play a potent role in normal development, tissue homeostasis, aging and a wide spectrum of age related disorders. Up to now, a major problem in the field of senescence was the absence of a reliable marker to specifically detect these cells, especially in situ. SenTraGor™ (GL13) is a biotinylated Sudan Black B based chemical reagent that was designed to overcome this constraint.

SenTraGor™ (GL13) staining allows the detection of senescence in any biological material. Direct visualization of senescent cells can be achieved in all archival tissue specimens (formalin-fixed paraffin-embedded) and cells from biopsies or cell cultures.

SenTraGor™ is recommended for the recognition of senescent cells. It binds to cytoplasmic lipofuscin, a hallmark of senescent cells. It can be applied on cells from aspiration or cell cultures as well as on tissue sections from frozen or formalin-fixed paraffin embedded (FFPE) samples. It can be used for immunohistochemistry (IHC), immunocytochemistry (ICC), immunofluorescence (IF) and flow cytometry analysis (FACS). Application of hybrid histochemical/ immunohistochemical assay is required to produce a consistent and specific signal. Use a primary anti-biotin antibody and secondary antibody against your primary anti-biotin antibody.

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